| March 19, 2011 | Tampa Yankees released RF Francisco Santana. |
| November 9, 2010 | OF Francisco Santana assigned to Aguilas Cibaenas. |
| August 31, 2010 | RF Francisco Santana assigned to Tampa Yankees from Charleston RiverDogs. |
| June 24, 2010 | Francisco Santana assigned to Charleston RiverDogs from Tampa Yankees. |
| April 27, 2010 | Francisco Santana assigned to Tampa Yankees from Staten Island Yankees. |
| August 29, 2009 | Francisco Santana assigned to Staten Island Yankees from Trenton Thunder. |
| August 12, 2009 | Francisco Santana assigned to Trenton Thunder from Staten Island Yankees. |
| June 19, 2009 | Francisco Santana assigned to Staten Island Yankees from GCL Yankees. |
| May 30, 2009 | Francisco Santana assigned to GCL Yankees from DSL Yankees1. |